WebFeb 23, 2024 · SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available. This database provides information about selected rodent models of neurodegenerative disease, including Alzheimer’s, Parkinson’s, and ALS. WebJul 17, 2024 · PINK1 and Parkin (encoded by PRKN) are involved in the clearance of damaged mitochondria in cultured cells 4, but recent evidence obtained using knockout and knockin mouse models have led to...
Basal Mitophagy Occurs Independently of PINK1 in …
WebPINKCAT Wireless Mouse, 2.4G Slim Silent Cordless Mouse with USB Receiver, 3 Adjustable DPI Portable Optical Wireless Computer Mice for Laptop, PC, Notebook, … WebWe used a well-established transgenic mouse model of CMT2A with R94Q mutation on MFN2 gene (MFN2 R94Q) to investigate the functional and morphological changes in retina. We documented extensive vision loss due to photoreceptor degeneration, retinal ganglion cell and their axonal loss, retinal secondary neuronal and synaptic alternation, and ... fwirrpp
PINK1 antibody (23274-1-AP) Proteintech - ptglab
WebThe results showed that the expression levels of PINK1 and Parkin, as markers of mitophagy in C2C12 cells, were significantly upregulated after exposure to MHT. However, enhanced O-GlcNAcylation of SIRT1 at residues T 160 and S 161 blocked the recruitment of Parkin by PINK1, thereby slowing the initiation of mitophagy. WebMay 25, 2012 · Background: Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) have been linked to familial Parkinson's disease, but the underlying pathogenic mechanism remains unclear. We previously reported that loss of PINK1 impairs mitochondrial respiratory activity in mouse brains. WebMar 20, 2014 · Mitochondrial-enriched fractions from Pink1 +/+ and Pink1 −/− mouse brain and liver were treated with 1% dodecyl maltoside, and the solubilized mitochondrial protein complexes were immunocaptured using 20-kD complex I subunit antibody. The immunocaptured complex I was further analyzed on SDS–polyacrylamide gel … fwhite67bossman